Modeling Thyroid Cancer in the Mouse

X-G. Zhu; S-Y. Cheng

doi:10.1055/s-0029-1215572

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2009; 41(6): 488-499
DOI: 10.1055/s-0029-1215572

Review

Modeling Thyroid Cancer in the Mouse

X-G. Zhu¹ , S-Y. Cheng¹

¹Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Abstract

Thyroid carcinomas, the most common endocrine tumors in humans, have an increasing incidence in the U.S. and worldwide. There are four major types of thyroid cancers: papillary, follicular, anaplastic, and medullary carcinomas. In recent years, significant progress has been made in the identification of genetic alterations in thyroid carcinomas, particularly, papillary and medullary thyroid cancers. Mouse models of thyroid cancer are valuable tools in elucidating molecular genetic changes underlying thyroid carcinogenesis and in identifying potential molecular targets for therapeutic intervention. Representative mouse models of papillary, follicular, and medullary carcinomas are reviewed here with particular emphasis on those for follicular thyroid carcinomas. Challenges for further development in the modeling of thyroid cancer will also be discussed.

Key words

thyroid cancer - thyroid hormone - mouse models

Volltext

Referenzen

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S-y. Cheng

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National Cancer Institute

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